2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. HMG-CoA Reductase (HMGCR)
  5. HMG-CoA Reductase (HMGCR) Degrader

HMG-CoA Reductase (HMGCR) Degrader

HMG-CoA Reductase (HMGCR) Degrader (1):

Cat. No. Product Name Effect Purity
  • HY-171823
    PROTAC HMGCR Degrader-1
    		Degrader
    PROTAC HMGCR Degrader-1 is an orally active HMGCR PROTAC degrader with IC50 of 1.32 μM. PROTAC HMGCR Degrader-1 is a lactone prodrug of PROTAC HMGCR Degrader-2 (HY-181134). PROTAC HMGCR Degrader-1 achieves high plasma exposure of the active ingredient leading to robust HMGCR degradation and demonstrating promising cholesterol-lowering efficacy in vivo. PROTAC HMGCR Degrader-1 can be used for hyperlipidemia research.